Four healthy daughters were born, but the only male heir to the throne, Alexei, showed signs of bleeding and bruising at 6 weeks of age.ħ Alexei Having a brother, an uncle and two cousins who had suffered from the disorder and died at early ages, you can imagine the despair Alexandra felt for her son and the future heir. Irene’s sister, and Queen Victoria’s granddaughter, Alexandra, married Czar Nicholas 11 of Russia. One of her daughters, Irene, passed the trait to the next generation of Prussian royalty – 2 of her sons. Once of Alice’s sons, Frederick, died at the age of 3 from hemophilia. Two of their sons died from hemophilia in their early 30’s.Īlice, another of Victoria’s daughters, married Louis IV of Hesse, a member of the Prussian royal family and related to Prince Henry of Battenberg. Her daughter, Victoria, was a carrier and married King Alfonso XIII of Spain, thus transmitting the gene to the Spanish royal family. Two of their sons inherited the trait, both dying before the age of 35. Queen Victoria’s daughter Beatrice, a carrier for the trait, married Prince Henry of Battenberg, a descendent of Prussian royalty. Her son Leopold had hemophilia and died as a result of a minor fall (hemophelia does not allow blood to clot, and as a result you can bleed to death from as little as a paper cut or stubbed toe!). Queen Victoria had 5 sons and 5 daughters. 2 One of the most famous examples of a pedigree demonstrating inheritance of a sex-linked trait is the family of Queen Victoria of England and hemophilia.
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